Lectin binding of human sperm associates with DEFB126 mutation and serves as a potential biomarker for subfertility
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چکیده
منابع مشابه
Methylated TRF2 associates with the nuclear matrix and serves as a potential biomarker for cellular senescence
Methylation of N-terminal arginines of the shelterin component TRF2 is important for cellular proliferation. While TRF2 is found at telomeres, where it plays an essential role in maintaining telomere integrity, little is known about the cellular localization of methylated TRF2. Here we report that the majority of methylated TRF2 is resistant to extraction by high salt buffer and DNase I treatme...
متن کاملthe 33.1 kda excretory/secretory protein produced by toxo-cara canis larvae serves as a potential common biomarker for serodiagnosis of toxocariasis in paratenic animals and human
background: toxocariasis is a prevalent zoonosis disease caused by the closely related nematode species toxocara canis and toxocara cati which parasitise canidae and felidae respectively. in paratenic hosts, larvae of these worms cause multiple organ damage. however, how these paratenic hosts response to these worms and whether any common biomarker can be applied for diagnosis are still unclear...
متن کاملHypomethylation of DNA-binding inhibitor 4 serves as a potential biomarker in distinguishing acquired tamoxifen-refractory breast cancer.
OBJECTIVE To explore the methylation status of DNA-binding inhibitor 4 (ID4) in tamoxifen-refractory (TR) breast cancer. METHODS From January 2012 to December 2014, breast cancer patients managed by radical mastectomy previously and receiving tamoxifen treatment for at least 12 months were enrolled. According to the response to tamoxifen, patients were divided into TR group and tamoxifen-sens...
متن کاملNEK2 serves as a prognostic biomarker for hepatocellular carcinoma
Never in mitosis gene A (NIMA)-related kinase 2 (NEK2) is a microtubule-associated protein that regulates spindle assembly in human cells and is overexpressed in various malignancies. However, the role of NEK2 in hepatocellular carcinoma (HCC) remains undetermined. We performed RNA-seq of the HCC cell line SMMC-7721 and the normal liver cell line HL-7702 using the Ion Proton System. NEK2 expres...
متن کاملa comparison of teachers and supervisors, with respect to teacher efficacy and reflection
supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep20249